P13K 1-phosphatidylinositol 3-kinase definition and studies

P13K 1-phosphatidylinositol 3-kinase definition

<enzyme>

<cell biology> An enzyme that catalyses the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, v(d)j recombination and cell cyle checkpoints.37.

Chemical name: ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase

Registry number: EC 2.7.1.137

Online Medical Dictionary

Additional studies on its role:

Effects of Tyroserleutide on Gene Expression of Calmodulin and P13K in Hepatocellular Carcinoma

Oncogenic P13K Deregulates Transcription and Translation

A role for phosphoinositol-3-kinase (P13K) in the stimulation of hepatic taurocholate uptake by cyclic AMP

Laminin-332 promotes the invasion of oesophageal squamous cell carcinoma via P13K activation

Patent application title: THIAZOLOPYRIMIDINE P13K INHIBITOR COMPOUNDS AND METHODS OF USE

Expression Status and Mutational Analysis of the PTEN and P13K Subunit Genes in Ovarian Granulosa Cell Tumors

High D-glucose alters PI3K and Akt signaling and leads to endothelial cell migration,

proliferation and angiogenesis dysfunction